Dong Y, Zheng P. Dehydroepiandrosterone sulphate: action and mechanism in the brain. J Neuroendocrinol. Activation of immune function by dehydroepiandrosterone DHEA in age-advanced men. Mayo Clinic. Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment.
Geriatr Gerontol Int. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. See more conditions. Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information. Please try again. Something went wrong on our side, please try again.
Show references DHEA. Natural Medicines. Accessed Jan. Pizzorono JE, et al. Dehydroepiandrosterone DHEA. In: Textbook of Natural Medicine. Elsevier; IBM Micromedex. Kellerman RD, et al. It might be necessary to take this supplement for longer periods to experience increased bone density, and this effect may be larger in older women.
Due to its ability to increase testosterone levels , many believe that DHEA can increase muscle mass or muscle strength However, the majority of research shows that taking DHEA supplements does not increase muscle mass or muscle performance. This has been shown in young, middle-aged and elderly adults over periods lasting from four weeks to one year 17 , 18 , 19 , 20 , 21 , 22 , Several studies showed that it did not improve physical performance in older adults, but others reported increased upper and lower body strength Overall, because a large number of studies show no benefits for muscle size or strength, DHEA is probably not effective in these two regards.
As with muscle mass, the majority of research indicates that DHEA is not effective at reducing fat mass 17 , 18 , 20 , 22 , 23 , 26 , This form of the supplement, called 7-Keto DHEA, has been reported to increase metabolic rate in overweight men and women In this study, individuals taking the supplement lost about 6.
Those in the placebo group only lost 2. Some research in women nearing menopause showed that women with depression had higher levels of this hormone than those without depression However, some individuals with severe depression have lower levels of DHEA than those with milder depression 6. Other studies have shown no improvements in mental function or depression scores in healthy, middle-aged and elderly adults 33 , 34 , Some researchers even caution against the use of it, as higher levels of DHEA in the body have been associated with increased symptoms of depression in middle-aged women For starters, DHEA supplements may improve the function of the ovaries in women with impaired fertility.
In fact, it increased the success of in vitro fertilization IVF in 25 women experiencing fertility problems Additionally, several studies have shown that these supplements may increase libido and sexual function in both men and women 38 , 39 , However, the largest benefits were seen in individuals with impaired sexual function. Often, no benefits were seen in individuals without sexual problems 41 , The adrenal glands, which sit on top of the kidneys, are one of the main producers of DHEA 1.
This condition can produce fatigue, weakness and changes in blood pressure. It can even progress to become life-threatening DHEA supplements have been examined as a way to treat symptoms of adrenal insufficiency.
Some research indicates that they may improve the quality of life in these individuals 44 , 45 , Given this hormonal milieu, an increase in serum IGF-I levels was observed in both genders but dimorphic responses were evident in fat body mass and muscle strength in favour of men.
Gov't, P.
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